The Ghana Football Association has asked Fifa, soccer's world governing body, to move the second leg of Ghana's 2014 World Cup play-off tie against Egypt next month to a neutral venue.
The match is due to be played in the Egyptian capital Cairo on November 19, but following more clashes in the city over the weekend that killed dozens of people, the GFA has written to Fifa citing concerns about security.
The GFA said in the letter, published on its website: "Our request is premised on the alarming and fast deteriorating security situation in Egypt. The violence has shown no sign of abating.
"We are seriously concerned about the security and safety of our delegation and spectators if the match would be played in Egypt as events in the country pointedly indicate that our delegation could be exposed to danger as the violence and insecurity in the country continues relentlessly."
Fifa said it was "monitoring the situation."
The game in Cairo would be Egypt's first home match in the 2014 qualifying campaign to have supporters in attendance. Domestic clubs Al Ahly and Zamalek played their recent CAF Champions League matches behind closed doors as the security authorities refused the supporters access to the games because of the current turmoil in the country.
The GFA said: "The 2014 Fifa World Cup qualifying matches involving the Central African Republic were moved to neutral venues due to political instability in that country. Much as we sympathise with our brothers at the Egyptian Football Association, we are highly concerned about the security and safety of our players, officials and supporters.
"We would like Fifa to take the necessary steps to protect lives and from both Ghana and Egypt during the second-leg game."
The first leg of the tie is due to be played in Kumasi, Ghana on October 15.